The role of intracellular zinc release in aging, oxidative stress, and Alzheimer's disease

Brain aging is marked by structural, chemical, and genetic changes leading to cognitive decline and impaired neural functioning. Further, aging itself is also a risk factor for a number of neurodegenerative disorders, most notably Alzheimer's disease (AD). Many of the pathological changes associated with aging and aging-related disorders have been attributed in part to increased and unregulated production of reactive oxygen species (ROS) in the brain. ROS are produced as a physiological byproduct of various cellular processes, and are normally detoxified by enzymes and antioxidants to help maintain neuronal homeostasis. However, cellular injury can cause excessive ROS production, triggering a state of oxidative stress that can lead to neuronal cell death. ROS and intracellular zinc are intimately related, as ROS production can lead to oxidation of proteins that normally bind the metal, thereby causing the liberation of zinc in cytoplasmic compartments. Similarly, not only can zinc impair mitochondrial function, leading to excess ROS production, but it can also activate a variety of extra-mitochondrial ROS-generating signaling cascades. As such, numerous accounts of oxidative neuronal injury by ROS-producing sources appear to also require zinc. We suggest that zinc deregulation is a common, perhaps ubiquitous component of injurious oxidative processes in neurons. This review summarizes current findings on zinc dyshomeostasis-driven signaling cascades in oxidative stress and age-related neurodegeneration, with a focus on AD, in order to highlight the critical role of the intracellular liberation of the metal during oxidative neuronal injury. © 2014 McCord and Aizenman

Spin Glass Computations and Ruelle's Probability Cascades

We study the Parisi functional, appearing in the Parisi formula for the pressure of the SK model, as a functional on Ruelle's Probability Cascades (RPC). Computation techniques for the RPC formulation of the functional are developed. They are used to derive continuity and monotonicity properties of the functional retrieving a theorem of Guerra. We also detail the connection between the Aizenman-Sims-Starr variational principle and the Parisi formula. As a final application of the techniques, we rederive the Almeida-Thouless line in the spirit of Toninelli but relying on the RPC structure.Comment: 20 page

Infrared bound and mean-field behaviour in the quantum Ising model

We prove an infrared bound for the transverse field Ising model. This bound is stronger than the previously known infrared bound for the model, and allows us to investigate mean-field behaviour. As an application we show that the critical exponent $\gamma$ for the susceptibility attains its mean-field value $\gamma=1$ in dimension at least 4 (positive temperature), respectively 3 (ground state), with logarithmic corrections in the boundary cases.Comment: 42 pages, 5 figures, to appear in CM

Localization criteria for Anderson models on locally finite graphs

We prove spectral and dynamical localization for Anderson models on locally finite graphs using the fractional moment method. Our theorems extend earlier results on localization for the Anderson model on \ZZ^d. We establish geometric assumptions for the underlying graph such that localization can be proven in the case of sufficiently large disorder

A non-perturbative method of calculation of Green functions

A new method for non-perturbative calculation of Green functions in quantum mechanics and quantum field theory is proposed. The method is based on an approximation of Schwinger-Dyson equation for the generating functional by exactly soluble equation in functional derivatives. Equations of the leading approximation and the first step are solved for $\phi^4_d$-model. At $d=1$ (anharmonic oscillator) the ground state energy is calculated. The renormalization program is performed for the field theory at $d=2,3$. At $d=4$ the renormalization of the coupling involves a trivialization of the theory.Comment: 13 pages, Plain LaTex, no figures, some discussion of results for anharmonic oscillator and a number of references are added, final version published in Journal of Physics

No quasi-long-range order in strongly disordered vortex glasses: a rigorous proof

The paper contains a rigorous proof of the absence of quasi-long-range order in the random-field O(N) model for strong disorder in the space of an arbitrary dimensionality. This result implies that quasi-long-range order inherent to the Bragg glass phase of the vortex system in disordered superconductors is absent as the disorder or external magnetic field is strong.Comment: 3 pages, Revte

The phase transition of the quantum Ising model is sharp

An analysis is presented of the phase transition of the quantum Ising model with transverse field on the d-dimensional hypercubic lattice. It is shown that there is a unique sharp transition. The value of the critical point is calculated rigorously in one dimension. The first step is to express the quantum Ising model in terms of a (continuous) classical Ising model in d+1 dimensions. A so-called `random-parity' representation is developed for the latter model, similar to the random-current representation for the classical Ising model on a discrete lattice. Certain differential inequalities are proved. Integration of these inequalities yields the sharpness of the phase transition, and also a number of other facts concerning the critical and near-critical behaviour of the model under study.Comment: Small changes. To appear in the Journal of Statistical Physic

Competition between fluctuations and disorder in frustrated magnets

We investigate the effects of impurities on the nature of the phase transition in frustrated magnets, in d=4-epsilon dimensions. For sufficiently small values of the number of spin components, we find no physically relevant stable fixed point in the deep perturbative region (epsilon << 1), contrarily to what is to be expected on very general grounds. This signals the onset of important physical effects.Comment: 4 pages, 3 figures, published versio

On Bernoulli Decompositions for Random Variables, Concentration Bounds, and Spectral Localization

As was noted already by A. N. Kolmogorov, any random variable has a Bernoulli component. This observation provides a tool for the extension of results which are known for Bernoulli random variables to arbitrary distributions. Two applications are provided here: i. an anti-concentration bound for a class of functions of independent random variables, where probabilistic bounds are extracted from combinatorial results, and ii. a proof, based on the Bernoulli case, of spectral localization for random Schroedinger operators with arbitrary probability distributions for the single site coupling constants. For a general random variable, the Bernoulli component may be defined so that its conditional variance is uniformly positive. The natural maximization problem is an optimal transport question which is also addressed here